Related Experiment Video
Updated: Aug 9, 2026

10:33
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation
Published on: September 4, 2017
Development of software for internal dose calculation from bioassay measurements
N Ishigure1, M Matsumoto, T Nakano
1Environmental Radiation Protection Research Group, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage, Chiba 263-8555, Japan. ishigure@nirs.go.jp
Radiation Protection Dosimetry
|July 16, 2004
Summary
New software, MONDAL2, simplifies interpreting bioassay data using advanced biokinetic models. This tool helps estimate radionuclide intake and effective dose for radiation protection of workers and the public.
Area of Science:
- Radiological Sciences
- Radiation Protection
- Biokinetics
Background:
- Recent International Commission on Radiological Protection (ICRP) biokinetic models offer realistic radionuclide behavior descriptions in the human body.
- Interpreting bioassay data with these advanced models is challenging due to complexity.
- A scarcity of user-friendly software exists for implementing these biokinetic models.
Purpose of the Study:
- To introduce MONDAL2 (Monitoring to Dose Calculation ver. 2), a personal computer-based software.
- To enable estimation of intake activity and effective dose from bioassay measurements.
- To support dose assessment for both occupationally exposed workers and the general public.
Main Methods:
- Development of MONDAL2 software utilizing advanced biokinetic models.
- Implementation on personal computers running Microsoft Windows operating systems.
- User-friendly interface for inputting bioassay data and obtaining dose estimations.
Main Results:
- MONDAL2 successfully estimates intake activity and effective dose from bioassay data.
- The software facilitates the practical application of complex biokinetic models.
- It provides a valuable tool for radiation dose assessment in various scenarios.
Conclusions:
- MONDAL2 addresses the need for accessible software in interpreting bioassay data.
- It enhances the practical application of ICRP biokinetic models for radiation protection.
- The software is freely distributed by the National Institute of Radiological Sciences.
Related Concept Videos
Biological Effects of Radiation
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
Measurement of Bioavailability: Pharmacodynamic Methods
Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.

