[Substitution for an experimental duodenal substance loss in the dog with an original bioreactive material]

The aim of this study was to evaluate the suitability of the Elastin Fibrin material as a patch to close a full thickness 1.5 cm diamater duodenal wall defect in the dog. This material originates from a reaction between elastin and fibrin monomers and is available in sheet form of differing thickness. Three Beagles underwent surgical creation of a duodenal defect ant the patch closure with elastin fibrin. Coelioscopic check of the patch was performed at day 8, 15, 39, 60, 90, 120. There was no morbidity or mortality. Macroscopic and histologic examination showed complete disappearance of the patch material and restitution of the duodenal wall at 6 months. These results suggest that in selected cases, evaluation in human may be justified.