Related Experiment Video
Updated: Aug 23, 2026

New Features in Visual Dynamics 3.0
Published on: August 9, 2024
CAR: detailing new models
1High Throughput Biology, Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.
Abstract:
Functional analysis has broadened our understanding of the physiological roles of the two related nuclear receptors pregnane X receptor (PXR; NR1I2) and constitutive androstane receptor (CAR; NR1I3). Initial research focused on the role of these two receptors in xenobiotic detoxification and, more recently, additional functional roles for CAR have been identified. Specifically, CAR activity has been shown to ameliorate the effects of hyperbilirubinemia, caloric restriction and toxic bile acids. Thus, the physiological role of CAR has broadened to include responses to metabolic and nutritional stress. These data highlight potential new opportunities in targeting CAR for drug discovery.
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