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Updated: Aug 23, 2026
A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization
Published on: January 20, 2023
[Eosinophil apoptosis in nasal polyposis tissue after bleomycin A5 local injection]
Xianghong Zhang1, Jidong Zou, Baoshu Li
1Department of Otorhinolaryngology, Second Hospital, Xi'an Jiaotong University, Xi'an, 710004, China.
Objective:
To study the expression of eosinophil in nasal polyposis tissue after Bleomycin A5 local injection.
Method:
Nineteen cases nasal polyposis specimen obtained before and after treatment with Bleomycin A5 were studied with terminal deoxynucleotidyl transferasemediated dUTP nick endlabeling (TUNEL).
Result:
The number of eosinophil in nasal polyposis specimen before treatment is significantly higher than that after treatment (P<0.01) and so to normal inferior turbinate concha mucosa (P<0.01). The apoptosis index (AI) of eosinophil after treatment is significantly higher than that before treatment (P<0.01).
Conclusion:
Eosinophil is the main infiltration cell in nasal polyposis tissue. Bleomycin A5 could cure nasal polyposis by promoting eosinophil apoptosis.
