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Perinatal stroke in children with motor impairment: a population-based study
Yvonne W Wu1, Whitney M March, Lisa A Croen
1Department of Neurology, University of California, San Francisco 94143-0136, USA. wuy@peds.ucsf.edu
Pediatrics
|September 3, 2004
Summary
Preeclampsia and intrauterine growth restriction are significant risk factors for perinatal arterial stroke (PAS) in infants, potentially leading to motor impairment. Further research is needed to fully understand PAS risk factors and outcomes.
Area of Science:
- Neurology
- Pediatrics
- Obstetrics
Background:
- Perinatal arterial stroke (PAS) risk factors are not well understood.
- Previous studies often lack appropriate control groups or focus only on newborns.
Purpose of the Study:
- To identify prenatal and perinatal risk factors for PAS.
- To investigate the association between maternal conditions and infant outcomes.
Main Methods:
- Population-based, case-control study.
- Included 231,582 singleton infants born at >=36 weeks gestation.
- Utilized medical record review for PAS diagnosis and random selection of controls.
Main Results:
- PAS prevalence was 17/100,000 live births, with 68% presenting after 3 months.
- Preeclampsia (OR: 3.6) and intrauterine growth restriction (OR: 5.3) were significant prepartum risk factors.
- Delivery complications like emergency C-section (OR: 6.8) and low Apgar scores (OR: 23.6) increased PAS risk.
Conclusions:
- Preeclampsia and intrauterine growth restriction (IUGR) may be independent risk factors for PAS.
- PAS can result in motor impairment, with delayed presentation common in moderate to severe cases.
- Larger studies are required to confirm risk factors and outcomes for all perinatal stroke cases.