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EPA Method 1615. Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. II. Total Culturable Virus Assay
11:09

EPA Method 1615. Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. II. Total Culturable Virus Assay

Published on: September 11, 2016

[Laboratory diagnostics of enterovirus cardiac infections]

T V Amvros'eva, N V Poklonskaia, O V D'iakonova

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |September 7, 2004
    PubMed

    Insights

    Diagnosing enterovirus cardiac infection (EVCI) is improved by identifying key markers. This study highlights antienterovirus IgM, viral proteins, and RNA in cardiac cells for accurate EVCI diagnosis.

    Area of Science:

    • Virology
    • Cardiology
    • Molecular Diagnostics

    Context:

    • Enterovirus cardiac infection (EVCI) is a significant cause of heart disease.
    • Accurate diagnostic markers for EVCI are crucial for effective patient management.
    • Current diagnostic methods may lack sensitivity or specificity.

    Purpose:

    • To evaluate the diagnostic efficacy of various markers for enterovirus cardiac infection (EVCI).
    • To identify reliable biomarkers for detecting EVCI in patients with cardiac conditions.
    • To develop an improved diagnostic scheme for EVCI.

    Summary:

    • The study analyzed clinical samples from patients with myocarditis, dilated cardiomyopathy, ischemic heart disease, and healthy donors.
    • Key diagnostic markers identified include antienterovirus IgM in serum, viral protein expression in myocardium, and the presence of viral RNA and replicative intermediates in cardiac cells.
    • These findings led to the development of an updated diagnostic scheme integrating clinical history, rapid diagnosis, and molecular analysis of cardiac biopsies.

    Impact:

    • Provides a more accurate and comprehensive diagnostic approach for enterovirus cardiac infection.
    • Enhances the ability to differentiate EVCI from other cardiac conditions.
    • Facilitates timely and appropriate treatment for patients with EVCI, potentially improving cardiac outcomes.

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