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Published on: October 17, 2016
[Compatibility research of self-designed scaffold biomaterials of nature extracellular matrix]
Yanjun Wang1, Weijia Kong, Shengbin Bi
1Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Objective:
Scaffold biomaterials for cell culture of tissue-engineering demand satisfactory biocompatibility. This experiment aimed to evaluate biocompatibility of self-designed scaffold biomaterial of NECM.
Method:
The biocompatibility of self-designed NECM was evaluated both in vivo and in vitro, including cytotoxic test, acute and subacute systemic toxicity test, hemolysis test, pyrogenic test, lymphocyte transformation test and long-term subcutaneous implantation test of NECM.
Result:
Self-designed NECM scaffold biomaterial for cell culture has no cytotoxicity, no acute and subacute systemic toxicity, and it did not cause inflammatory reaction.
Conclusion:
Self-designed NECM has good biocompatibility and may become an ideal biological scaffold material for cell culture of tissue engineering.
