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[A study on the expression of IL-8 and IL-3 in human nasal polyp and polyposis]
1Department of Otorhinolaryngology, the First Clinical Hospital, China Medical University, Shenyang, 110001, China.
Objective:
To study the expression of IL-8 and IL-3 in human nasal polyp and polyposis.
Method:
Using immunohistochemical methods detect the expressions of IL-8 and IL-3 in 52 cases of middle turbinate,nasal polyp and nasal polyposis,and calculating the positive area percentages in each group. All datas were analysed with SNK test, Kruskal-Wallis test and Mann-Whitney test.
Result:
There were very significant differences between either two groups about the expressions of IL-8. There were significant differences between either two groups about the expressions of IL-3.
Conclusion:
IL-8 is not only one of the causes in nasal polyp, but also plays an important role in the recurrence of nasal polyposis. The expression of IL-8 in polyp is different from that in polyposis, it indicate that polyp and polyposis have different mechanism. IL-3 is important for the accumulation of eosinophil and is a key factor in the mechanism of polyposis.
