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Updated: Aug 22, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Carotid artery stenting
1Division of Vascular Surgery, Department of Surgery, UMDNJ-NJMS ADMC, Building 6, Room 620, 30 Bergen Street, Newark, NJ 07101, USA. hobsonrw@umdnj.edu
Insights
Randomized trials are evaluating carotid artery stenting (CAS) versus carotid endarterectomy (CEA) for stroke prevention. Results from trials like CREST and CAVATAS will guide future treatment decisions for carotid artery disease.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Neurology
Background:
- Carotid endarterectomy (CEA) is the standard for carotid revascularization.
- Carotid artery stenting (CAS) efficacy requires confirmation via randomized clinical trials (RCTs) in standard-risk patients.
- Ongoing trials are comparing CAS and CEA for extracranial carotid occlusive disease management.
Purpose of the Study:
- To compare the efficacy and safety of carotid artery stenting (CAS) versus carotid endarterectomy (CEA).
- To provide evidence-based guidance for the management of symptomatic and asymptomatic extracranial carotid occlusive disease.
Main Methods:
- Initiation of randomization in North American CREST (Carotid Revascularization Endarterectomy versus Stent Trial) trial.
- Recruitment of symptomatic patients in European CAVATAS (Carotid and Vertebral Artery Transluminal Angioplasty Study) and SPACE trials for CEA vs. CAS comparison.
Main Results:
- Efficacy of CAS not yet confirmed by RCTs in conventional risk populations.
- Trials are actively recruiting and expected to yield definitive results within 1-3 years.
Conclusions:
- Results from ongoing RCTs (CREST, CAVATAS, SPACE) are anticipated to clarify the role of CAS relative to CEA.
- These findings will inform future clinical practice guidelines for carotid revascularization procedures.
Abstract:
Efficacy for carotid artery stenting (CAS) has not been confirmed by randomized clinical trial methodology in conventional risk patients. Although carotid endarterectomy (CEA) is considered the preferred method for carotid revascularization in the management of patients with symptomatic and asymptomatic extracranial carotid occlusive disease, comparisons between CAS and CEA are now underway. In North America, the CREST (Carotid Revascularization Endarterectomy versus Stent Trial) protocol is now completing its lead-in or credentialing phase as randomization of cases is initiated. In Europe, the CAVATAS (Carotid and Vertebral Artery Transluminal Angioplasty Study) and Stent Protected Angioplasty versus Carotid Endarterectomy trials are recruiting symptomatic patients for randomization between CEA and CAS. It is anticipated that these trials will publish definitive results within the next 1 to 3 years, and help guide the referral of patients for CAS and CEA in the future.
