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Updated: Aug 5, 2026

Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy
Published on: June 8, 2018
[Mechanisms of carcinogenesis associated with DNA repair]
Abstract:
The paper presents data from the literature and the author's own materials on the correlation between the extent of activity of reparation processes and the development of cell malignization. A review cites the results of investigations on the molecular mechanisms in some hereditary human diseases in which a defect in some stages of the reparation processes has been found (xeroderma, ataxia telangesthesia. Fanconi anemia, Down's syndrome, etc.). These diseases are also characterized by a high rate of neoplasia development. It is emphasized that inhibition of the reparation process is observed only in the first stages of normal cell transformation into a malignant one. A correlation between carcinogenic and mutagenic activity of chemical compounds which is in favour of the mutation hypothesis of the origin of tumours is discussed.
Insights
DNA repair activity is linked to cell malignization. Defective repair in hereditary diseases correlates with increased cancer risk, suggesting repair inhibition is key in early tumor development.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
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