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Published on: September 19, 2014
Local recurrence in lumpectomy patients after imprint cytology margin evaluation
Elizabeth Weinberg1, Charles Cox, Elisabeth Dupont
1Comprehensive Breast Cancer Program, Department of Surgery, H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, 12902 Magnolia Dr., Tampa, FL 33612, USA.
American Journal of Surgery
|October 12, 2004
Summary
Intraoperative imprint cytology (IIC(M)) for lumpectomy margins significantly reduces local recurrence rates in breast cancer patients. This method improves margin evaluation, lowering 5-year recurrence from 8.8% to 2.8%.
Area of Science:
- Oncology
- Surgical Pathology
- Breast Cancer Research
Background:
- Follow-up study on local recurrence rates after lumpectomy.
- Investigating the impact of intraoperative imprint cytology (IIC(M)) on margin evaluation.
- Comparing recurrence rates between IIC(M)-evaluated and conventionally evaluated lumpectomy margins.
Purpose of the Study:
- To compare local recurrence rates in breast cancer patients treated with lumpectomy.
- To assess the efficacy of intraoperative imprint cytology (IIC(M)) in evaluating lumpectomy margins.
- To determine if IIC(M) evaluation leads to lower local recurrence rates compared to conventional methods.
Main Methods:
- Prospective study of 1713 breast cancer patients undergoing lumpectomy (1988-2001).
- Group 1 (520 patients): Conventional margin analysis at an outside institution.
- Group 2 (1193 patients): Intraoperative imprint cytology (IIC(M)) margin evaluation at our institution.
- Kaplan-Meier method used for estimating recurrence probabilities over time.
Main Results:
- Intraoperative imprint cytology (IIC(M)) overcomes sampling errors inherent in frozen section analysis.
- Overall 5-year local recurrence rate decreased from 8.8% to 2.8% with IIC(M) (P <0.0001).
- Recurrence rates reported for specific histologic subtypes and overall, including absolute and time-dependent probabilities.
Conclusions:
- Intraoperative imprint cytology (IIC(M)) provides accurate lumpectomy margin evaluation for breast-conservation treatment.
- IIC(M) is associated with a significantly lower overall local recurrence rate.
- This study defines the clinical utility of intraoperative imprint cytology for margin assessment in breast cancer surgery.
