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Plasmapheresis in acute disseminated encephalomyelitis
Chin-Hsien Lin1, Jiann-Shing Jeng, Ping-Keung Yip
1Department of Neurology, National Taiwan University Hospital, Taipei.
Journal of Clinical Apheresis
|October 20, 2004
Summary
Plasmapheresis effectively treated two acute disseminated encephalomyelitis (ADEM) patients unresponsive to corticosteroids. This suggests plasmapheresis may be a valuable treatment option for ADEM, potentially even as a first-line therapy.
Area of Science:
- Neurology
- Immunology
Background:
- High-dose corticosteroids are the primary treatment for acute disseminated encephalomyelitis (ADEM).
- Some ADEM patients exhibit poor response to standard corticosteroid therapy.
Observation:
- Two ADEM patients received plasmapheresis treatment.
- Patient symptoms and clinical outcomes were compared with existing literature.
Findings:
- Plasmapheresis demonstrated successful treatment outcomes in the observed ADEM cases.
- The treatment appears beneficial for severe ADEM cases refractory to corticosteroids.
Implications:
- Plasmapheresis could be considered for ADEM patients unresponsive to high-dose corticosteroids.
- Further research, including large controlled trials, is necessary to establish plasmapheresis as a first-line ADEM treatment.