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Updated: Aug 21, 2026
Experimental Models for Study of Retinal Pigment Epithelial Physiology and Pathophysiology
Published on: November 6, 2010
Experimental study of effect of perfluorohexyloctane to retina
Chunfang Li1, Xiaoyan Ding, Lin Lu
1Zhongshan Ophthalmic center, Sun Yet-san University, Guangzhou 510060 , China.
Objective:
To investigate the effect of perfluorohexyloctane to the retina of rabbit eyes.
Methods:
Perfluorohexyloctane (experimental group) or BSS(control group) into vitreous cavities of fifteen vitrectomized New Zealand white rabbits. A slit-lamp biomicroscope and an indirect ophthalmoscope were used to examine all the eyes pre- and postoperation. Histopathological examination was performed after the rabbits were sacrificed.
Results:
Perfluorohexyloctane was injected into the vitreous cavity forming a single large layerclear globe. No retinal detachment and cataract were found. The edema of outer plexiform was significant, and then get a darker cytoplasm and nucleoplasm.
Conclusions:
Perfluorohexyloctane in vitreous cavity had significant side effects on retina. As a silicone solvent, it should be removed out completely after injection. We don't recommend to use it as a new intraocular tamponade.
