[An experimental study on repair of laryngeal cartilage defect with the bone morphogenetic protein composite]

To study the effects of the bone matrix gelatin and composite of bone morphogenetic protein and fibrin glue (BMP-FG) on the repair of thyroid cartilage defect.

Full-thickness defects measuring 0.4 cm x 0.4 cm were created in four sections in thyroid cartilages of 20 adult dogs. The defects were divided into 4 groups by the sections they in. Group A was empty group, without implant; Group B were repaired by implanted with hydroxylapatite; Group C with bone matrix gelatin (containing BMP); Group D with bone morphogenetic protein-fibrin glue composite. The animals were killed separately at 2, 4, 12 weeks after operation. The effects of repair were analyzed by routine histological examination and electron microscope.

In the BMP-FG implanted group, the result showed complete absorption of the implant and substitution by new-formed cartilage and bone. The defects in the BMG group regenerated less cartilage and bone, the inflammation was sever. The gross appearance and histological features of HA group were similar to the empty group.

Both BMP-FG and BMG can induce cartilage and bone regeneration to repair the defect of thyroid cartilage. BMP-FG has a better effect.