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[Experimental study of taxol combining accelerated radiation on laryngeal carcinoma cells]
1Department of Otorhinolaryngology-Head and Neck Surgery, Renji Hospital of Shanghai Second Medical University, Shanghai 200001.
Objective:
To investigate the effect of taxol combining accelerated radiation on the human laryngeal squamous cell carcinoma Hep-2 cell lines in vitro, and to provide the experimental basis for the usage of these two combined theraputic methods.
Method:
Using techniques of tumor cells culture in vitro, the suppressive and time-dependency effects of taxol (1 x 10(-8) mol/L) combine 2 Gy X-rays generated by accelerator on the human laryngeal squamous cell carcinoma Hep-2 cell lines were observed.
Result:
Cell growth is obviously suppressed in group taxol combined accelerated radiation and it's livability is 11.11%, much lower than accelerated radiation combined taxol. After adding taxol 12 h or 24 h then combined accelerated radiation, the two groups were no difference statistically. Cell livability of group taxol is lower than group accelerated radiation.
Conclusion:
Cell growth is obviously suppressed in the human laryngeal squamous cell carcinoma Hep-2 cell lines after given 1 x 10(-8) mol/L taxol combined 2 Gy X-rays generated by accelerator. Taxol acts as a radiation sensitizer.
