Related Experiment Video
Updated: Aug 9, 2026
Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
[Expression of p15 protein in poorly differentiated nasopharyngeal carcinoma]
Chuanyu Liang1, Fawen Zhang, Xiangguo Zeng
1Department of Otorhinolaryngology, Western China Hospital of Sichuan University, Chengdu 610041.
Objective:
To explore the role of p15 protein in the pathogenesis of poorly differentiated nasopharyngeal carcinoma (NPC).
Method:
Using immunohistochemical LSAB (Labeled Streptavidin Biotin method), we examined 55 samples of poorly differentiated NPC and 15 samples of nasopharyngeal normal tissue for expression of p15 protein.
Result:
The p15 protein expression was located in the cytoplasm and nuclear membranes. The positive rate of p15 protein in NPC is significantly lower than that in normal tissue (P < 0.05). Important correlations were found between the p15 protein expression and clinic stages, T classification of NPC. But p15 protein wasn't correlated to neck lymph node metastasis and 5-years survival rate.
Conclusion:
The absence of p15 protein may play an important role in the pathogenesis and development of NPC, the expression of p15 protein may be used to evaluate the biological behavior of NPC.
