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Updated: Aug 21, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Stereoconservative Negishi arylation and alkynylation as an efficient approach to enantiopure 2,2'-diarylated
Katarína Krascsenicsová1, Peter Walla, Peter Kasák
1Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Slovak Republic.
Abstract:
Negishi arylation and alkynylation of easily synthesized chiral 2,2'-diodo-1,1'-binaphthyl rapidly proceeds in refluxing THF utilizing controlled microwave irradiation, affording enantiopure 2,2'-diarylated 1,1'-binaphthyls in good to excellent yields.
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