Related Experiment Video
Updated: Jul 27, 2026
04:53
An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
[New aspects in uv and photochemotherapy]
1Zentrum für Dermatologie und Venerologie der Johann-Wolfgang-Goethe-Universität Frankfurt.
Summary
Topical PUVA therapy (psoralen plus ultraviolet A) is more effective and safer than systemic PUVA. Narrowband UVB and UVA1 phototherapy show promise for various skin conditions like psoriasis and atopic dermatitis.
Area of Science:
- Dermatology
- Phototherapy
- Pharmacology
Context:
- Phototherapy is a cornerstone in treating various skin conditions.
- Systemic PUVA therapy has been a common treatment but is associated with significant side effects.
- Emerging evidence suggests topical and newer phototherapy modalities offer improved safety and efficacy profiles.
Purpose:
- To review the current data on topical PUVA, narrowband UVB, and UVA1 phototherapy.
- To compare the efficacy and side effect profiles of different phototherapy regimens.
- To highlight the shift towards safer and more effective phototherapy options in dermatology.
Summary:
- Topical (cream or bath) PUVA therapy demonstrates superior pharmacological benefits and a reduced side effect profile compared to systemic PUVA, leading to its increased adoption.
- Narrowband ultraviolet B (UVB) therapy is more effective than broadband UVB for psoriasis and beneficial for conditions like vitiligo and atopic dermatitis.
- UVA1 phototherapy is highly effective for moderate to severe atopic dermatitis and sclerosing skin diseases, with medium-dose UVA1 showing comparable efficacy to high-dose regimens.
Impact:
- The findings support the transition from systemic to topical PUVA, improving patient safety and treatment outcomes.
- Advancements in UVB and UVA1 phototherapy expand treatment options for a range of dermatological disorders.
- This review guides clinical practice towards evidence-based phototherapy selection for enhanced dermatological care.
More Related Videos
11:04An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
Published on: January 13, 2023
13:17In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
Published on: September 29, 2023
Related Concept Videos
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:02Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview
Ultraviolet–visible (UV–visible or UV–Vis) spectroscopy is an analytical technique that investigates the interaction between matter and UV–Vis light within the electromagnetic spectrum. This method is widely used for its versatility, simplicity, and relatively quick data acquisition, making it valuable for both qualitative and quantitative analysis. When UV–Vis radiation passes through a material, molecules absorb light depending on the energy required for electronic transitions. As a result...
01:26Photochemical Electrocyclic Reactions: Stereochemistry
The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
Selection Rules: Photochemical Activation
01:35Mutations
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
01:16UV–Vis Spectroscopy: Molecular Electronic Transitions
In Ultraviolet–Visible (UV–Vis) spectroscopy, the absorption of electromagnetic radiation is used to probe the electronic structure of molecules. This technique provides insights into molecular electronic transitions, particularly the movement of electrons between different molecular orbitals. Radiation is absorbed if the energy of the electromagnetic radiation passing through the molecule is precisely equal to the energy difference between the excited and ground states. During this process,...
01:14UV–Vis Spectrometers
The absorbance of UV and visible (UV–visible) radiations is measured using a UV–visible spectrophotometer. Deuterium lamps, which emit UV radiation, and tungsten lamps, which produce radiation in the visible region, are used as light sources in UV–visible spectrophotometers. A monochromator or prism is used for diffraction grating, i.e., to split the incoming radiation into different wavelengths. A system of slits is used to focus the desired wavelength on the sample cell. Samples for...