Related Experiment Videos
Integrated CMOS amplifier for ENG signal recording.
A Uranga1, X Navarro, N Barniol
1Electronic Engineering Department, Universitat Autónoma de Barcelona, 08193-Bellaterra, Spain. Arantxa.Uranga@uab.es
IEEE Transactions on Bio-Medical Engineering
|December 21, 2004
Summary
This study presents a novel CMOS amplifier for recording neural signals. The developed device effectively captures neural activity in rats, demonstrating its potential for biomedical applications.
Area of Science:
- Biomedical Engineering
- Electronics Engineering
- Neuroscience
Background:
- Extracellular neural signal recording is crucial for understanding neural activity.
- Conventional amplifiers often suffer from flicker noise, limiting performance.
- Integrated CMOS technology offers potential for miniaturized and efficient neural recording devices.
Purpose of the Study:
- To develop and validate a fully integrated differential CMOS amplifier for extracellular neural signal acquisition.
- To minimize flicker noise using a chopper technique for improved signal-to-noise ratio.
- To assess the amplifier's performance in vivo using animal models.
Main Methods:
- Fabrication of a differential CMOS amplifier using standard 0.7-microm CMOS technology.
- Implementation of a chopper technique to reduce flicker noise.
- In vivo testing with acute rat experiments, recording various neural signals.
Main Results:
- The amplifier achieved a gain of 74 dB and a bandwidth of 3 kHz.
- Input-referred noise was measured at 6.6 nV/(Hz)0.5.
- Low power dissipation (1.3 mW) and a compact active area (2.7 mm2) were achieved.
- Successful recording of compound muscle action potentials, motor unit action potentials, and compound nerve action potentials.
Conclusions:
- The developed integrated CMOS amplifier is suitable for recording extracellular neural signals.
- The chopper technique effectively minimized flicker noise.
- The amplifier's performance in vivo validates its utility for neurophysiological studies.