Label free colorimetric biosensing using nanoparticles
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Updated: Sep 13, 2026

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A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
Published on: November 24, 2015
Nidhi Nath1, Ashutosh Chilkoti
1Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Journal of Fluorescence
|December 25, 2004
Abstract:
In this review article, we discuss a class of biosensors that exploit the change in the colorimetric properties of noble metal nanoparticles in response to biomolecular binding at their surface. Several sensor fabrication techniques as well as sensor configurations are discussed with an emphasis on their strengths and limitations. We conclude by presenting the future prospects and challenges for the successful transition of this technology from the laboratory to a commercial product.

