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[Oral second generation antihistamines in allergic rhinitis]
1Univ.-HNO-Klinik Ulm.
Laryngo- Rhino- Otologie
|January 14, 2005
Summary
Second generation antihistamines effectively reduce allergic rhinitis symptoms like nasal itch and sneezing. These medications offer convenient, safe, once-daily relief for intermittent nasal allergies with minimal side effects.
Area of Science:
- Allergy and Immunology
- Pharmacology
Background:
- Histamine is a primary mediator of immediate allergic reactions.
- Antihistamines are frequently used to treat allergic rhinitis.
Purpose of the Study:
- To review the effects of histamine and antihistamines on allergic rhinitis.
- To evaluate the efficacy and safety of second-generation antihistamines.
Main Methods:
- Literature search of the National Library of Medicine for current data.
- Analysis of histamine receptor actions and antihistamine mechanisms.
Main Results:
- Histamine activates H1, H2, H3, and H4 receptors, influencing nasal symptoms and inflammation.
- Second-generation antihistamines block H1 receptors, reducing nasal itch, sneezing, and hypersecretion.
- These antihistamines improve physical and mental performance and are safe for daily use.
Conclusions:
- Oral second-generation antihistamines are effective for treating intermittent nasal allergy.
- Minimal adverse effects and efficient symptom reduction make them ideal for mild to moderate cases.