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Updated: Aug 20, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete
Published on: January 24, 2025
[The 100 years since discovery of Spirochaeta pallida]
1Klinik für Dermatologie und Venerologie, Vívantes-Klinikum Neukölln, Berlin. peter.kohl@vivantes.de
Abstract:
On 3 March 1905, Fritz Schaudinn, Erich Hoffmann and Fred Neufeld, working in the women's ward of the Department of Dermatology at the Charite Hospital in Berlin, became the first people in the world to observe the causative agent of syphilis, Treponema pallidum. The pathogen's etiological significance was subsequently demonstrated by Schaudinn and Hoffmann and other scientists. The detection of Treponema pallidum was the first decisive step towards the development of diagnostic and therapeutic procedures in subsequent years.
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