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Preparation and investigation of inclusion complexes containing nitrazepam
1Department of Pharmaceutical Technology, Albert Szent-Györgyi Medical University, Szeged.
Acta Pharmaceutica Hungarica
|January 1, 1992
Abstract:
Nitrazepam is a valuable drug, being one of the often used minor tranquillizers in psychotherapy. However, its solubility characteristics are very unfavourable. Products were prepared with dimethyl-beta-cyclodextrin in different combinations (8.58%, 19.48% and 27.29%) and by several methods such as mixing, kneading, precipitation and spray-drying.