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Pediatric renal transplantation: single center experience
Sevgi Mir1, Hakan Erdoğan, Erkin Serdaroğlu
1Department of Pediatric Nephrology, Ege University Medical School, Izmir, Turkey.
Pediatric Transplantation
|January 26, 2005
Summary
Pediatric renal transplantation (RTx) shows good graft and patient survival rates, with no correlation found between survival and donor type, complications like hypertension, or infections such as CMV and HCV.
Area of Science:
- Pediatric Nephrology
- Transplantation Medicine
- Immunology
Background:
- Renal transplantation (RTx) is the preferred treatment for pediatric end-stage renal disease, yet fewer children receive transplants compared to adults.
- Individual pediatric transplant center experience significantly impacts outcomes for pediatric transplant recipients.
Purpose of the Study:
- To present the experience and outcomes of pediatric renal transplantation at a single center.
- To analyze graft and patient survival rates and identify factors influencing them.
Main Methods:
- Retrospective analysis of 72 pediatric renal transplants performed between June 1989 and May 2003.
- Kaplan-Meier method used to calculate graft and patient survival rates.
- Correlation analysis performed for various factors including donor type, complications, and infections.
Main Results:
- Graft survival rates at 1, 5, and 10 years were 91%, 84%, and 77%, respectively.
- Patient survival rates at 1, 5, and 10 years were 97%, 84%, and 77%, respectively.
- Common complications included hypertension (31.9%), acute rejection (27.8%), and urinary tract infections (43.1%). Cytomegalovirus (CMV) and hepatitis C virus (HCV) infections were noted in 20.8% and 16.7% of patients, respectively.
Conclusions:
- Pediatric renal transplantation at this center demonstrated favorable long-term graft and patient survival.
- Survival outcomes were not significantly correlated with sex, donor type, rejection episodes, hypertension, or CMV/HCV infections.