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Updated: Aug 19, 2026

Cerebral Ischemic Coma Model Induced by Modified Four-Vessel Occlusion
Published on: July 5, 2024
[Carotid occlusive disease presenting with loss of consciousness]
Daina Kashiwazaki1, Satoshi Kuroda, Shunsuke Terasaka
1Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Insights
Occlusive carotid artery disease can cause syncope (loss of consciousness). This study found that treating these conditions, via surgery or medication, prevented further fainting episodes in male patients.
Area of Science:
- Neurology
- Vascular Surgery
- Radiology
Context:
- Syncope, or fainting, can be a symptom of serious underlying conditions.
- Occlusive carotid artery disease involves blockages in the neck arteries supplying the brain.
Purpose:
- To investigate the link between occlusive carotid artery disease and syncope.
- To evaluate the outcomes of treating these patients.
Summary:
- Nine male patients (59-83 years) with syncope due to internal carotid artery (ICA) occlusion or severe stenosis were studied.
- Imaging revealed cerebral infarction in some patients, with reduced cerebral perfusion reserve noted in four.
- Surgical revascularization or medical management successfully resolved syncope in all patients during follow-up.
Impact:
- Highlights the importance of considering carotid artery disease in the differential diagnosis of syncope.
- Demonstrates the effectiveness of surgical and medical interventions in managing syncope secondary to carotid artery disease.
Abstract:
The authors report 9 patients who presented with loss of consciousness (syncope) due to occlusive carotid artery diseases. All patients were males, and their age ranged from 59 to 83 years. The attack was associated with dehydration or hypotension in 5 patients. MRI demonstrated fresh cerebral infarction in the watershed zone. Cerebral angiography revealed occlusion of the unilateral internal carotid artery (ICA) in 7 patients, severe stenosis of the bilateral ICA in one, and occlusion of the unilateral ICA and severe stenosis of the contralateral ICA in one. Single photon emission tomography (SPECT) or positron emission tomography (PET) suggested reduced cerebral perfusion reserve because of inappropriate development of collateral circulation in 4 out of 9 patients. These 4 patients underwent superficial temporal artery to middle cerebral artery anastomosis and/or carotid endarterectomy. Other 5 patients were medically treated. No further episode of syncope occurred in all 9 patients during follow-up periods. The results suggest that occlusive carotid artery diseases should be taken in considerations as a cause of syncope attack.
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