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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Acaricidal daphnane diterpenoids from Trigonostemon reidioides (KURZ) CRAIB roots
Noppamas Soonthornchareonnon1, Monnun Sakayarojkul, Masahiko Isaka
1Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. pynsk@mahidol.ac.th
Abstract:
A new daphnane diterpenoid, rediocide F (1), was isolated together with three known compounds, rediocides A (2), C (3) and E (4), from the hexane extract of Trigonostemon reidioides roots by bioassay-guided fractionation for acaricidal activity on Dermatophagoides pteronyssinus, Thai common house dust mite. The structure of rediocide F (1) was established as the demethyl analog of rediocide C (3) on the basis of spectral analysis. Compounds 1-4 exhibited potent activity against D. pteronyssinus with respective LC50 values of 2.53, 0.78, 5.59 and 0.92 microg/cm2.
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