Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Segregation and linkage analysis.

R C Elston1

  • 1Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans 70112.

Animal Genetics
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder.

Molecular psychiatry·2014
Same author

Familial dyslexia: genetic and medical findings in eleven three-generation families.

Annals of dyslexia·2013
Same author

An efficient algorithm to compute the posterior genotypic distribution for every member of a pedigree without loops.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

The finite polygenic mixed model: An alternative formulation for the mixed model of inheritance.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Lack of evidence for segregation of a single dominant major gene as the cause of the difference in egg weight between two highly inbred lines of chickens.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

An algorithm to approximate the likelihood for pedigree data with loops by cutting.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same journal

Genome-Wide Association Study and Genomic Prediction for Maximum Litter Size in Sows.

Animal genetics·2026
Same journal

Transcriptomic Analysis Reveals Multilayer Regulation Underlying Development and Pregnancy in the Malayan Pangolin.

Animal genetics·2026
Same journal

Gestational Feed Restriction Induces Differential Expression of Novel Long Non-Coding RNAs in Offspring Skeletal Muscle.

Animal genetics·2026
Same journal

A NECAP1 Nonsense Variant is Associated With Leukoencephalomyelopathy With Oligodendroglial Dysplasia in a Belgian Malinois With Spinocerebellar Ataxia.

Animal genetics·2026
Same journal

Enrichment Analysis of Differentially Expressed Genes During Feather Regeneration in Landes Geese (Anser anser).

Animal genetics·2026
Same journal

Multi-Omics Analysis Reveals Impacts of SCARB1, TYR, and TYRP1 Knockouts on Pigmentation and Metabolic Pathways in Oujiang Color Common Carp.

Animal genetics·2026
See all related articles

This study introduces the SAGE software package for human geneticists, enabling segregation and linkage analyses in pedigrees. It can detect major genes influencing quantitative traits, even those contributing only 10% to trait variation.

Area of Science:

  • Human genetics
  • Statistical genetics
  • Bioinformatics

Background:

  • Segregation and linkage analyses are crucial for understanding human genetic diseases.
  • Identifying genes that influence complex traits requires robust analytical methods.
  • Existing methods may have limitations in detecting genes with small effects.

Purpose of the Study:

  • To introduce the SAGE software package for genetic analyses.
  • To provide tools for segregation and linkage analysis in human pedigrees.
  • To enable the detection of major genes contributing to quantitative trait variation.

Main Methods:

  • Utilizes the SAGE software package.
  • Performs segregation analysis on pedigree data from non-inbred populations.

Related Experiment Videos

  • Employs linkage analysis with polymorphic markers.

    • Main Results:

    • The SAGE package facilitates a variety of genetic analyses.
    • Methods are specifically designed for major gene segregation.
    • Detection of loci contributing as little as 10% to quantitative trait variation is possible.

    Conclusions:

    • SAGE software provides valuable tools for human geneticists.
    • The methods are effective in non-inbred populations.
    • Detecting genes with moderate effects on quantitative traits is feasible with these methods.