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A peptide-catalyzed asymmetric Stetter reaction
Steven M Mennen1, Jarred T Blank, Michelle B Tran-Dubé
1Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA.
Chemical Communications (Cambridge, England)
|February 23, 2005
Abstract:
Thiazolylalanine, in appropriately functionalized form, has been found to function as an enantioselective catalyst for an intramolecular Stetter reaction. Incorporation of the residue in a number of environments has resulted in a family of catalysts that promote the cyclization of a test substrate with up to 81% enantiomeric excess.