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Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
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Published on: August 4, 2011

Management of advanced retinoblastoma

Santosh G Honavar1, Arun D Singh

  • 1Ocular Oncology Service and SightSavers International Children's Eye Cancer Center, LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad 500034, India. honavar@lvpei.org

Ophthalmology Clinics of North America
|March 15, 2005
PubMed

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...