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Systemic non-Hodgkin's lymphoma simulating primary intraocular lymphoma
Anup H Parikh1, Sameer H Khan, John D Wright
1Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina, USA.
American Journal of Ophthalmology
|March 16, 2005
Summary
Systemic non-Hodgkin's lymphoma can mimic primary intraocular lymphoma. This case highlights the importance of considering systemic lymphoma in the differential diagnosis of unusual intraocular inflammation and subretinal lesions.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Systemic non-Hodgkin's lymphoma (NHL) is a diverse group of lymphoid malignancies.
- Primary intraocular lymphoma (IOL) is a rare form of extranodal lymphoma confined to the eye.
Observation:
- A 58-year-old woman with a history of treated systemic NHL presented with a subretinal lesion and intraocular inflammation.
- Clinical and histopathologic findings closely resembled primary intraocular lymphoma.
Findings:
- Diagnostic enucleation and histopathology confirmed intraocular tumor cells consistent with primary intraocular lymphoma.
- Tumor cells were found intraretinally, subretinally, and in the subretinal pigment epithelium, without choroidal involvement.
Implications:
- Systemic NHL can present with ocular manifestations mimicking primary intraocular lymphoma.
- This underscores the need to include systemic lymphoma in the differential diagnosis of intraocular inflammation and subretinal infiltrates.