Related Experiment Video
Updated: Aug 19, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
[Molecular mechanism of vascular calcification in renal failure]
Ichiro Ohkido1, Hajime Saikawa, Hiroshi Hayakawa
1Division of Nephrology and hypertension, Department of Internal Medicine, Jikei University School of Medicine.
Abstract:
Vascular calcification is the most frequent cause of death in chronic renal failure. In recent studies molecular mechanism for regulation of vascular calcification is becoming to clear. An important regulator of vascular calcification is the extracellular levels of inorganic phosphate. Also, various bone matrix proteins and factors regulates vascular calcification in ESRD patients.
Related Concept Videos
Diabetic Nephropathy
Osteoclasts in Bone Remodeling
Skeleton and Calcium Homeostasis
Urinary Tract Calculi I: Introduction
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

