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Cerebral activation patterns during working memory performance in multiple sclerosis using FMRI.

Nancy Chiaravalloti1, Frank Hillary, Joseph Ricker

  • 1Kessler Medical Rehabilitation Research and Education Corporation, 1199 Pleasant Valley Way, West Orange, NJ 07052, USA.

Journal of Clinical and Experimental Neuropsychology
|April 9, 2005
PubMed
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Working memory deficits in Multiple Sclerosis (MS) are linked to altered brain activity. Individuals with MS and working memory impairment showed increased right-sided brain activation compared to healthy controls.

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Neurology

Background:

  • Working memory deficits are prevalent in Multiple Sclerosis (MS).
  • Functional magnetic resonance imaging (fMRI) studies on working memory dysfunction in MS are limited.
  • Understanding cerebral activation patterns is crucial for addressing cognitive impairments in MS.

Purpose of the Study:

  • To investigate brain activation patterns during a working memory task in individuals with MS compared to healthy controls (HC).
  • To identify differences in cerebral activation associated with working memory impairment in MS.
  • To determine if altered activation is specific to cognitive impairment in MS.

Main Methods:

  • fMRI scans were acquired during a modified Paced Auditory Serial Addition Test (mPA-SAT).

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  • Participants included individuals with MS (with and without working memory impairment) and HC.
  • Data were analyzed using Statistical Parametric Mapping (SPM99) with a significance level of alpha < .005.

    • Main Results:

    • All groups performed the task comparably.
    • Healthy controls and MS groups without impairment showed similar left-lateralized frontal activation patterns.
    • The MS group with working memory impairment exhibited greater right frontal and right parietal lobe activation compared to HC.

    Conclusions:

    • Working memory dysfunction in MS is associated with distinct patterns of cerebral activation.
    • Altered brain activation in MS-related working memory deficits is linked to the presence of cognitive impairment.
    • These findings differentiate cognitive impairment from general effects of MS on brain function.