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[Visceral leishmaniasis: a study of 15 cases]
F Laguna1, E Gazapo, P Martínez
1Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid.
Anales De Medicina Interna (Madrid, Spain : 1984)
|April 1, 1992
Summary
This study details 15 adult visceral leishmaniasis cases, highlighting successful treatment with meglumine antimoniate in most patients. Early diagnosis and treatment are crucial for managing this parasitic disease.
Area of Science:
- Infectious Diseases
- Parasitology
- Internal Medicine
Background:
- Visceral leishmaniasis (VL) is a severe parasitic disease.
- Prompt diagnosis and effective treatment are critical for patient outcomes.
Purpose of the Study:
- To describe the clinical presentation, diagnosis, and treatment outcomes of visceral leishmaniasis in adult patients.
- To evaluate the efficacy and safety of meglumine antimoniate in treating VL.
Main Methods:
- Retrospective case series of 15 adult patients diagnosed with visceral leishmaniasis.
- Diagnosis confirmed by parasite visualization or clinical, serological, and treatment response criteria.
- Treatment administered using meglumine antimoniate.
Main Results:
- Fifteen adult cases of visceral leishmaniasis were identified.
- Common symptoms included fever, constitutional syndrome, and visceromegaly.
- Hematological abnormalities such as anemia, leukopenia, and thrombocytopenia were prevalent.
- Serology was positive in 75% of cases.
- Meglumine antimoniate treatment was successful in 14 patients with no adverse effects or recurrences.
- One patient died from septic shock.
Conclusions:
- Meglumine antimoniate is an effective and safe treatment for visceral leishmaniasis in adults.
- Clinical and laboratory findings are important for diagnosis, alongside parasitological confirmation.
- Vigilance for complications like septic shock is necessary.