Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Concepts in nuclear architecture.

Tom Misteli1

  • 1National Cancer Institute, NIH, Bethesda, MD 20892, USA. mistelit@mail.nih.gov

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|April 16, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome reorganization and its functional impact during breast cancer progression.

eLife·2026
Same author

Connecting multiway enhancer-promoter interactions to changes in gene expression in cancer.

bioRxiv : the preprint server for biology·2026
Same author

Orderly mitosis shapes interphase genome architecture.

eLife·2026
Same author

TAD boundaries and gene activity are uncoupled.

eLife·2026
Same author

Acute degron-mediated RUNX1 loss reprograms enhancer activity to epigenetically drive epithelial destabilization and initiate cancer hallmarks.

bioRxiv : the preprint server for biology·2026
Same author

Protocol to measure transcriptional bursting of endogenous genes using high-throughput RNA-FISH.

STAR protocols·2026
Same journal

AI in Genomics: From Variant Calling to Multi-Omics Integration.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Rethinking One Health: Microbial Foundations for Ecological Governance.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Hidden Fungal DNA Structures May Shape Sequencing Outcomes.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
See all related articles

Nuclear architecture significantly influences genome function beyond DNA sequence. Understanding spatial genome organization is crucial for comprehending gene regulation, cellular processes, and disease.

Area of Science:

  • Genomics
  • Cell Biology
  • Molecular Biology

Background:

  • Genome function relies on complex regulatory mechanisms beyond primary DNA sequence.
  • Nuclear architecture, including spatial and temporal organization, is an emerging key factor in genome regulation.
  • The role of nuclear organization in fundamental cellular processes is not fully understood.

Purpose of the Study:

  • To provide an overview of emerging concepts in in vivo genome organization and function.
  • To highlight the importance of nuclear architecture in understanding genome regulation.
  • To emphasize the need for integrated analysis of cellular and molecular aspects of genome organization.

Main Methods:

  • Combined cell biological, molecular, and computational analyses.

Related Experiment Videos

  • Investigation of architectural aspects of genome function.
  • Study of in vivo genome organization.

    • Main Results:

    • Genome function is influenced by multiple layers of regulatory control.
    • Spatial and temporal organization of genomes and regulatory proteins are critical control mechanisms.
    • Nuclear architecture plays a significant role in transcription and genome integrity maintenance.

    Conclusions:

    • Elucidating the contribution of nuclear architecture to gene expression is essential for understanding physiology and disease.
    • Nuclear organization is a critical determinant of genome function.
    • Further research integrating various analytical approaches is needed to fully understand genome organization and function.