Related Experiment Video
Updated: Aug 18, 2026

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
Published on: January 16, 2015
Carcinogenic potential of trans-2-hexenal is based on epigenetic effect
Edit Nádasi1, Tímea Varjas, László Pajor
1Department of Public Health and Preventive Medicine, Faculty of Medicine, University of Pécs, 7624 Pécs, Szigeti u. 12, Hungary. edit.nadasi@aok.pte.hu
Background:
Trans-2-hexenal (2-hexenal) is an alpha,beta-unsaturated carbonyl compound protecting plants against harmful substances. Since humans have a permanent intake of 2-hexenal via vegetable products, this genotoxic and mutagenic compound is considered to play a role in human carcinogenicity.
Materials And Methods:
Ha-ras and p53 gene expression changes and tumor development were investigated in mice and rats after 2-hexenal administration.
Results:
2-Hexenal exposure did not result in gene expression alterations 24, 48 or 72 hours after administration while 10 out of the 72 mice and rats included in the long-term study developed a malignancy by the end of the 18-month follow-up.
Conclusion:
Our results suggest that, although 2-hexenal showed no effect on the expression of the investigated onco- and suppressor genes, it has a marked carcinogenic potential, which may be explained only by an epigenetic effect of the compound.
More Related Videos
04:12Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
12:15Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
Published on: May 29, 2019
Related Concept Videos
Mutagenicity and Carcinogenicity
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
Toxicity Testing in Animals
Cancer Prevention
Some...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...