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Antiseptic "resistance": real or perceived threat?
1Antibiotic and Antiseptic Consultants, Silver Spring, MD 20910, USA. ATSheldon@Starpower.net
Summary
Biocides used in healthcare and communities may lead to microorganisms developing resistance to both biocides and antibiotics. More research is needed to understand and manage these risks effectively.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Biocides (antiseptics, disinfectants, preservatives, sterilants) are vital for preventing infections in clinical settings and communities.
- Microorganisms can develop resistance to biocides through intrinsic or acquired mechanisms, similar to antibiotic resistance.
- This resistance can be spread via plasmids and transposons, posing a significant public health concern.
Purpose of the Study:
- To review the current understanding of biocide resistance in microorganisms.
- To highlight the potential risks associated with biocide use in clinical and community settings.
- To emphasize the need for further research to guide safe biocide development and application.
Main Methods:
- Review of in vitro studies on biocide exposure and resistance mechanisms.
- Analysis of microbial adaptation strategies, including plasmid and transposon-mediated resistance.
- Assessment of current scientific evidence regarding biocide risks and benefits.
Main Results:
- In vitro data suggest biocide exposure can reduce susceptibility to antibiotics and biocides.
- Microorganisms utilize resistance mechanisms (e.g., plasmids, transposons) for survival and dissemination.
- Existing evidence is insufficient to fully weigh the risks versus benefits of biocide use.
Conclusions:
- Biocide use necessitates careful consideration of microbial resistance development.
- Additional research is crucial for characterizing risks in clinical and community environments.
- Further investigation is needed to inform appropriate precautions for biocide development and use.