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Miscibility gap in the microbial fitness landscape.

F N Braun1, S Paulsen, R P Sear

  • 1Institute of Medical Biology, University of Tromso, N-9037 Tromso, Norway.

Physical Review Letters
|May 21, 2005
PubMed
Summary

Microbial protein expression profiles exhibit a demixing instability. Many microbes exist near this instability, potentially linking it to evolutionary compartmentalization.

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Area of Science:

  • Molecular statistical mechanics
  • Microbial systems biology
  • Evolutionary biology

Background:

  • Biological systems often require stable protein expression for function.
  • Protein expression profiles can be analyzed in moment space.
  • Microbial life exhibits diverse strategies for managing cellular processes.

Purpose of the Study:

  • To investigate the existence and implications of demixing instability in microbial protein expression.
  • To compare theoretical findings with empirical proteomic and genomic data.
  • To explore the evolutionary significance of proximity to this instability.

Main Methods:

  • Application of molecular statistical considerations to protein expression data.
  • Analysis of microbial protein expression profiles in moment space.
  • Comparative analysis with existing proteomic and genomic datasets.

Main Results:

  • A demixing instability was identified in the moment space of microbial protein expression.
  • Many microbes were found to operate near the onset of this instability.
  • Proximity to the instability may be linked to evolutionary adaptations.

Conclusions:

  • The identified demixing instability is a significant feature of microbial protein expression.
  • Microbial evolution may involve navigating or utilizing this instability.
  • Intracellular compartmentalization could be an evolutionary response related to this phenomenon.

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