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Poly-L-lactic acid as a facial filler
1Laser and Skin Surgery Center of Indiana, Carmel, IN, USA.
Skin Therapy Letter
|June 30, 2005
Summary
Poly-L-lactic acid (PLLA) is an FDA-approved filler for facial lipoatrophy in HIV patients. While effective, PLLA requires multiple treatments, offers temporary results, and is costly.
Area of Science:
- Dermatology
- Biomaterials Science
Background:
- Facial lipoatrophy is a common concern, particularly in patients with human immunodeficiency virus (HIV).
- Poly-L-lactic acid (PLLA) is a synthetic biodegradable filler that has gained attention for soft tissue augmentation.
Purpose of the Study:
- To review the role of Poly-L-lactic acid (PLLA) as a filler for facial lipoatrophy.
- To discuss its FDA approval, off-label uses, and limitations.
Main Methods:
- Review of existing literature and FDA approval data for PLLA in aesthetic medicine.
- Analysis of PLLA's application in HIV-associated lipoatrophy and age-related facial volume loss.
Main Results:
- Poly-L-lactic acid (PLLA) is the sole FDA-approved filler for facial lipoatrophy in HIV-infected individuals.
- Off-label use of PLLA is expanding to address age-related lipoatrophy in non-HIV patients.
- PLLA treatment necessitates multiple sessions for optimal correction.
Conclusions:
- Poly-L-lactic acid (PLLA) offers a viable option for facial lipoatrophy correction, but its efficacy is tempered by temporary outcomes and high cost.
- Further research may explore optimizing PLLA treatment protocols and cost-effectiveness.
