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Schizophrenia: genes at last?

M J Owen1, N Craddock, M C O'Donovan

  • 1Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. owenmj@cardiff.ac.uk

Trends in Genetics : TIG
|July 13, 2005
PubMed
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Schizophrenia susceptibility is primarily genetic, involving multiple genes with small to moderate effects. Key candidate genes like dysbindin (DTNBP1) and neuregulin 1 (NRG1) show strong evidence, advancing schizophrenia research.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Schizophrenia susceptibility is influenced by genetic factors, with individual variations attributed to multiple genes.
  • Previous research has identified potential genetic linkage regions and chromosomal abnormalities associated with schizophrenia.

Purpose of the Study:

  • To review and consolidate evidence for candidate genes implicated in schizophrenia susceptibility.
  • To highlight genes with strong supporting data and those requiring further investigation.

Main Methods:

  • Analysis of genetic epidemiological and molecular genetic studies.
  • Evaluation of evidence for positional candidate genes, including DTNBP1, NRG1, DISC1, DAO, DAOA, and RGS4.

Main Results:

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  • Strong evidence supports dysbindin (DTNBP1) and neuregulin 1 (NRG1) as positional candidate genes for schizophrenia.
  • Promising, yet not conclusive, data exists for disrupted in schizophrenia 1 (DISC1), D-amino-acid oxidase (DAO), DAOA, and regulator of G-protein signalling 4 (RGS4).

Conclusions:

  • Identification of schizophrenia susceptibility genes offers new pathways for understanding disease pathogenesis.
  • These genetic findings may prompt a re-evaluation of psychiatric disorder classification.