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Multidrug resistant typhoid fever: study of an outbreak in Calcutta
Insights
This study found most childhood typhoid fever cases were resistant to common antibiotics. Ciprofloxacin effectively treated multidrug-resistant typhoid fever in children with no side effects.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Typhoid fever remains a significant pediatric health concern.
- Increasing antimicrobial resistance in Salmonella Typhi poses treatment challenges.
Purpose of the Study:
- To investigate the antimicrobial resistance patterns of typhoid fever in children.
- To evaluate the efficacy of ciprofloxacin in treating multidrug-resistant typhoid fever.
Main Methods:
- Retrospective analysis of 103 pediatric typhoid fever cases.
- Antimicrobial susceptibility testing for common antibiotics.
- Clinical evaluation of ciprofloxacin treatment outcomes.
Main Results:
- 82.5% of isolates were resistant to chloramphenicol, ampicillin, and co-trimoxazole.
- Gentamicin and furazolidine were ineffective against multidrug-resistant strains.
- Ciprofloxacin demonstrated 100% efficacy in treating 85 cases with no adverse effects.
Conclusions:
- Multidrug-resistant typhoid fever is prevalent in pediatric populations.
- Ciprofloxacin is a safe and effective treatment option for multidrug-resistant typhoid fever in children.
Abstract:
Of 103 cases of typhoid fever admitted to the Pediatric Wing of our hospital during the months of August 1989 to April 1990, 82.5% were resistant to chloramphenicol, ampicillin and co-trimoxozole. Nearly 87% children were in the age group of 3-10 years. Fever was present in all and splenomegaly in 90.2% cases. Urinary retention during the course of illness was present in 2 cases. The positivity rate of blood culture, bone marrow culture and Widal test was 83.7, 100 and 13.5%, respectively. Majority of the strains were of Phage 51-Type I. For the treatment of multidrug resistant cases gentamicin and furazolidine proved ineffective. Ciprofloxacin was tried in 85 cases and was found to be effective in all cases with no side effects.