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Isolation and Selection of Entomopathogenic Fungi from Soil Samples and Evaluation of Fungal Virulence against Insect Pests
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Eleven new 2-pyrones from a Fungi Imperfecti, Trichurus terrophilus, found in a screening study guided by

Haruhiro Fujimoto1, Yoshie Okamoto, Eriko Sone

  • 1Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. fujimoto@p.chiba-u.ac.jp

Chemical & Pharmaceutical Bulletin
|August 5, 2005
PubMed

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...