Related Experiment Video
Updated: Aug 16, 2026
A Workflow to Quantitatively Determine Age-Related Macular Degeneration Lesion-Specific Variations in Fundus Autofluorescence
Published on: May 26, 2023
Photodynamic therapy for choroidal neovascularization on late-onset fundus flavimaculatus
Eric H Souied1, Dominique Pawlak, Michel Algan
1Clinique Ophtalmologique Universitaire de Créteil, Créteil, France. eric.souied@chicreteil.fr
Purpose:
To report the features of three consecutive cases of patients affected with late-onset fundus flavimaculatus (FFM) complicated with choroidal new vessels (CNV) and treated with photodynamic therapy (PDT).
Design:
Retrospective interventional case series.
Methods:
Three unrelated women (70- to 74-year-old) presented with unilateral decrease of central vision. Diagnosis of FFM and unilateral CNV was made after fundus examination and fluorescein angiography (FA). PDT was performed on the basis of FA features.
Results:
One to three PDTs were needed for the treatment of CNV. At the end of follow-up (15-24 months), no leakage was present and visual acuity was improved in these three cases.
Conclusions:
Occurrence of CNV is a rare event in FFM. In these three eyes, PDT successfully stopped the progression of CNV and blocked leakage. We suggest considering PDT as a treatment for CNV in patients affected with FFM.