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Published on: January 22, 2021

Clinical characteristics of linezolid-resistant Staphylococcus aureus infections

Michael J Peeters1, Juan C Sarria

  • 1School of Pharmacy, Texas Tech University Health Sciences Center, Lubbock, 77555, USA.

The American Journal of the Medical Sciences
|August 17, 2005
PubMed

Insights

Linezolid resistance in Staphylococcus aureus is a growing concern. Prolonged therapy (>21 days) often precedes resistance, necessitating careful consideration of this antibiotic option.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Linezolid is a crucial antibiotic for treating serious Gram-positive bacterial infections.
  • Previous case reports documented linezolid resistance in Staphylococcus aureus.

Observation:

  • This report details an additional case of linezolid-resistant Staphylococcus aureus.
  • Patients often had invasive procedures, deep organ involvement, or foreign materials.

Findings:

  • Linezolid resistance developed after prolonged treatment (over 21 days) in most documented cases.
  • Clinical characteristics associated with resistance were identified.

Implications:

  • Clinicians must consider the risk of linezolid resistance when prescribing this antibiotic.
  • Further research into mechanisms and management of linezolid resistance is warranted.

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