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Updated: Aug 16, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

[Relationship between fibrinogen content and the protracted inflammation of secretory otitis media]

Xuan Wu1, Xihui Chen, Bin Huang

  • 1Department of Otolaryngology, the First Affiliated Hospital, Sun-Yat-Sen University, Guangzhou, 510080, China. wuxuan2005@21cn.com

Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology
|August 20, 2005
PubMed
Abstract

Insights

Elevated fibrinogen levels correlate with persistent inflammation in secretory otitis media (SOM). Higher fibrinogen concentrations indicate a poorer treatment outcome for this middle ear condition.

Area of Science:

  • Otolaryngology
  • Biochemistry
  • Inflammation Research

Context:

  • Secretory otitis media (SOM) is a common pediatric condition.
  • Protracted inflammation can lead to complications like middle ear adhesions.
  • Current treatment efficacy for chronic SOM varies.

Purpose:

  • To investigate the association between fibrinogen levels and persistent inflammation in secretory otitis media.
  • To determine if fibrinogen concentration can serve as a biomarker for treatment resistance in SOM.

Summary:

  • This study monitored fibrinogen content in 98 patients with SOM using the von Clauss technique.
  • Patients with protracted inflammation showed significantly higher fibrinogen levels compared to those cured.
  • Recurrent protracted cases exhibited even further elevated fibrinogen concentrations, suggesting a dose-dependent relationship.

Impact:

  • Fibrinogen may play a crucial role in the pathophysiology of chronic SOM and middle ear adhesion formation.
  • Findings suggest fibrinogen levels could aid in predicting treatment outcomes for SOM.
  • This research opens avenues for exploring fibrinogen-targeted therapies for refractory SOM.

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