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Ethnic differences predicting ketonuria in patients with Type 2 diabetes.
Rasa Kazlauskaite1, Arthur T Evans, Theodore Mazzone
1John H. Stroger, Jr. Hospital of Cook County, 1900 W. Polk Street, Chicago, IL 60612, USA; Rush University, Chicago, IL 60612, USA. rasa_kazlauskaite@rush.edu
Journal of Diabetes and Its Complications
|August 23, 2005
Summary
Ketonuria is common in Type 2 diabetes patients, especially in minority populations. Younger age, higher hemoglobin A1c, and substance abuse predict ketonuria, with ethnic differences noted.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Diabetes Mellitus Research
Background:
- Ketonuria is more prevalent than ketoacidosis in Type 2 diabetes.
- Ketonuria may indicate future serious health events.
- Understanding ketonuria correlates is crucial for patient management.
Purpose of the Study:
- To investigate the predictors of ketonuria in African American and Hispanic/Latino patients with Type 2 diabetes.
- To determine if ketonuria predictors vary by ethnic group.
- To explore the association between ketonuria and demographic/clinical factors.
Main Methods:
- Retrospective cross-sectional study of 228 patients with Type 2 diabetes.
- Data collected from emergency department and urgent care clinic referrals (2001-2003).
- Logistic regression analysis used to identify predictors of ketonuria and assess ethnic variations.
Main Results:
- 49% of patients exhibited ketonuria.
- Independent predictors included younger age, higher hemoglobin A1c, and substance abuse history.
- Hispanic/Latino patients showed an association between ketonuria and low HDL-cholesterol, unlike African American patients.
Conclusions:
- Ketonuria is frequent in newly diagnosed/untreated Type 2 diabetes patients in urban public hospitals serving minority populations.
- Ethnic differences in ketonuria correlates suggest variations in ketogenesis.
- Further research on ketonuria is vital for optimizing diabetes therapy and predicting ketoacidosis risk.