Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tolerance and withdrawal issues with sedation.

Antonia Zapantis1, Simon Leung

  • 1Department of Pharmacy Practice, College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Fort Lauderdale, FL 33328, USA. zapantis@nsu.nova.edu

Critical Care Nursing Clinics of North America
|August 24, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of the Sodium-Glucose Cotransporter Inhibitors on Cardiovascular Death and All-Cause Mortality: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Clinical Trials.

American journal of cardiovascular drugs : drugs, devices, and other interventions·2022
Same author

How Dangerous Is Too Dangerous? A Perspective on Azide Chemistry.

The Journal of organic chemistry·2022
Same author

Recognition of Advanced Pharmacy Practice Experience Student Participation Within Antimicrobial Stewardship Activities.

The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians·2021
Same author

The FDA Funding Crisis.

The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians·2021
Same author

The Impact of Anticoagulation on COVID-19 (SARS CoV-2) Patient Outcomes: A Systematic Review.

Journal of pharmacy practice·2021
Same author

Treatment of gastrointestinal bleeding with idarucizumab in a patient receiving dabigatran.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2018
Same journal

A New Era of Nursing Innovation.

Critical care nursing clinics of North America·2026
Same journal

Advancing Outcomes Through Innovation.

Critical care nursing clinics of North America·2026
Same journal

The Arc of Nurse Anesthesia: From Battlefield Origins to Future Innovation.

Critical care nursing clinics of North America·2026
Same journal

A Sepsis-Informed Model of Accelerated Aging.

Critical care nursing clinics of North America·2026
Same journal

TeleCritical Care Reimagined: Efficiency Through Digital Communication Application.

Critical care nursing clinics of North America·2026
Same journal

Impacts and Outcomes of Intensive Care Unit Design.

Critical care nursing clinics of North America·2026
See all related articles

This study evaluates tolerance and withdrawal from common ICU sedatives like benzodiazepines and propofol. Understanding these effects is crucial for safe patient care and managing sedative discontinuation.

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Patient Safety

Background:

  • Intensive Care Unit (ICU) stays involve complex patient care balancing optimal treatment with safety.
  • Reducing patient anxiety during ICU stays is essential, often managed with reorientation and sedation.
  • Commonly used sedatives include benzodiazepines, propofol, and dexmedetomidine, alongside other agents for pain control.

Purpose of the Study:

  • To evaluate the occurrence of tolerance and withdrawal syndromes.
  • To assess these complications in the most frequently used sedatives in critically ill patients.

Main Methods:

  • Review of common sedative agents used in ICUs.
  • Analysis of the incidence of tolerance and withdrawal associated with these agents.

Related Experiment Videos

  • Focus on benzodiazepines, propofol, and dexmedetomidine.

    • Main Results:

    • Sedation is frequently complicated by tolerance, potentially leading to withdrawal upon abrupt discontinuation.
    • The study examines the specific risks of tolerance and withdrawal for key sedative medications.
    • Incidence data for tolerance and withdrawal are evaluated for commonly administered sedatives.

    Conclusions:

    • Tolerance and withdrawal are significant complications of sedative use in critically ill patients.
    • Careful management and monitoring are necessary when discontinuing sedatives to mitigate withdrawal.
    • Further research into managing sedative-induced tolerance and withdrawal is warranted.