Related Experiment Video

Updated: Aug 16, 2026

Electrochemotherapy of Tumours
03:57

Electrochemotherapy of Tumours

Published on: December 15, 2008

[Investigational treatment of cancer using electrochemotherapy, electrochemoimmunotherapy and electro-gene transfer]

Julie Gehl1

  • 1Herlev Amtssygehus, Onkologisk Afdeling, Herlev. juge@herlevhosp.kbhamt.dk

Ugeskrift for Laeger
|August 25, 2005
PubMed

Insights

Electroporation uses electrical pulses to temporarily open cell membranes, enhancing drug delivery for cancer treatment (electrochemotherapy) and enabling non-viral gene therapy.

Area of Science:

  • Biotechnology
  • Cell Biology
  • Medical Technology

Context:

  • Electroporation involves applying electrical pulses to permeabilize cell membranes.
  • This technique facilitates the uptake of molecules that normally cannot cross the cell membrane.

Purpose:

  • To enhance cellular uptake of molecules, such as cytotoxic agents for electrochemotherapy.
  • To explore electroporation's potential in tumor lysis for immunotherapy.
  • To investigate new clinical applications in non-viral gene delivery.

Summary:

  • Electroporation is a method using high-voltage electrical pulses to create temporary pores in cell membranes.
  • It significantly improves the cellular absorption of non-permeating substances, including drugs used in electrochemotherapy.
  • The technique shows promise as a tumor lysis strategy in conjunction with immunotherapy and for novel non-viral gene delivery.

Impact:

  • Expands therapeutic options for cancer treatment through electrochemotherapy.
  • Offers a potential adjunctive approach for tumor lysis in immunotherapy.
  • Paves the way for innovative clinical applications in non-viral gene therapy and drug delivery.

More Related Videos

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats06:32

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...