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A novel method for assessing arterial endothelial function using phase contrast magnetic resonance imaging:
Harry A Silber1, Pamela Ouyang, David A Bluemke
1Division of Cardiology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA. hsilber@jhmi.edu
Summary
This study shows that phase contrast magnetic resonance imaging (PCMRI) can measure arterial constriction during reduced blood flow. This technique offers a new way to assess endothelial function.
Area of Science:
- Vascular Biology
- Medical Imaging
- Cardiovascular Physiology
Background:
- Endothelial function is crucial for vascular health.
- Reduced shear stress is a key factor in endothelial dysfunction.
- Non-invasive methods are needed to evaluate endothelial-dependent responses.
Purpose of the Study:
- To determine if phase contrast magnetic resonance imaging (PCMRI) can quantify endothelial-dependent arterial constriction.
- To assess changes in femoral artery radius and shear rate during reduced flow.
Main Methods:
- Phase contrast magnetic resonance imaging (PCMRI) was used to image the femoral artery in 33 subjects.
- Distal occlusion was applied for 5 minutes to reduce shear stress.
- Systolic shear rate and arterial radius were calculated from the velocity profile.
Main Results:
- Systolic shear rate significantly decreased immediately after occlusion (p < .0001).
- Femoral artery radius showed a significant decrease at 2 minutes into occlusion (p < .0001).
Conclusions:
- PCMRI can successfully measure arterial constriction in response to reduced blood flow.
- This imaging technique provides a novel method for comprehensive endothelial function assessment.