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08:59
Defining Substrate Specificities for Lipase and Phospholipase Candidates
Published on: November 23, 2016
Phospholipase D: a lipid centric review
1Department of Pharmacology, University Medical Center at Stony Brook, 495 CMM, Stony Brook, New York, 11794-5140, USA. jenkins@pharm.sunysb.edu
Cellular and Molecular Life Sciences : CMLS
|September 7, 2005
Summary
Phospholipase D (PLD) generates phosphatidic acid, a key lipid mediator. This review explores mammalian PLD
Area of Science:
- Biochemistry
- Cell Biology
- Lipid Metabolism
Background:
- Phospholipase D (PLD) hydrolyzes phosphatidylcholine, producing phosphatidic acid and choline.
- Phosphatidic acid is a crucial intracellular lipid mediator for PLD functions.
- PLD activity is conserved across diverse organisms, including mammals, plants, and microbes.
Purpose of the Study:
- To review the lipid precursors and products of mammalian PLD metabolism.
- To elucidate the roles of phosphatidic acid in mediating PLD functions.
- To highlight the regulation of PLD by various cellular components.
Main Methods:
- Literature review of mammalian PLD metabolism.
- Analysis of lipid mediators involved in PLD signaling pathways.
- Examination of regulatory mechanisms controlling PLD activity.
Main Results:
- Phosphatidic acid is a central product of PLD activity.
- Phosphatidic acid regulates diverse cellular processes, including cytoskeletal dynamics, vesicle trafficking, and receptor signaling.
- PLD is regulated by lipids like phosphatidylinositol-4,5-bisphosphate and signaling proteins.
Conclusions:
- Phosphatidic acid is a critical mediator of mammalian PLD functions.
- Understanding PLD metabolism and phosphatidic acid signaling is vital for comprehending cellular regulation.
- Further research into PLD regulation and its downstream effects is warranted.
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