Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

EPR spectrometer for clinical applications.

I Salikhov1, T Walczak, P Lesniewski

  • 1EPR Center for the Study of Viable Systems, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.

Magnetic Resonance in Medicine
|September 30, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pericytes Are Odontoblast Progenitor Cells Depending on ER Stress.

Journal of dental research·2025
Same author

Publisher Correction: A comparative effectiveness pilot study of teriparatide for medication-related osteonecrosis of the jaw: daily versus weekly administration.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2024
Same author

Isotropy of Cosmic Rays beyond 10^{20}  eV Favors Their Heavy Mass Composition.

Physical review letters·2024
Same author

An extremely energetic cosmic ray observed by a surface detector array.

Science (New York, N.Y.)·2023
Same author

A phase II evaluation of pembrolizumab in recurrent microsatellite instability-high (MSI-H) endometrial cancer patients with Lynch-like versus MLH-1 methylated characteristics (NCT02899793).

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Hydrocephalus due to marked enlargement of spinal roots in a patient with chronic inflammatory demyelinating polyradiculoneuropathy.

European journal of neurology·2020
Same journal

Feasibility and SNR Performance of Hyperpolarized <sup>129</sup>Xe Gas Exchange Imaging Using a Balanced SSFP Sequence.

Magnetic resonance in medicine·2026
Same journal

Multi-Contrast Human Brain CEST MRI at 11.7 T: First In Vivo Demonstration.

Magnetic resonance in medicine·2026
Same journal

Suppression of Oscillation and Ghosting in RF-Spoiled Gradient-Echo-Based Dynamic Imaging.

Magnetic resonance in medicine·2026
Same journal

A Simple, Dynamic Geometric Phantom for MRI and CT Reconstruction Pipelines: Beyond Shepp-Logan.

Magnetic resonance in medicine·2026
Same journal

7T 3D-EPI PCASL With High SNR Efficiency and Robustness to Through-Plane B<sub>0</sub> Field Gradients.

Magnetic resonance in medicine·2026
Same journal

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

Magnetic resonance in medicine·2026
See all related articles

This study presents a new human EPR spectrometer for non-invasive measurements. Its design enables versatile clinical applications, including oximetry and radiation dose assessment.

Area of Science:

  • Biomedical Engineering
  • Spectroscopy
  • Medical Physics

Background:

  • Electron Paramagnetic Resonance (EPR) spectroscopy offers unique insights into biological systems.
  • Existing EPR systems are often not optimized for direct human application, limiting clinical translation.
  • There is a need for specialized EPR instrumentation for in vivo human studies.

Purpose of the Study:

  • To describe the design and construction of a novel EPR spectrometer tailored for human measurements.
  • To highlight the features enabling clinical applicability and patient comfort.
  • To introduce initial applications in human health monitoring and diagnostics.

Main Methods:

  • Development of a permanent magnet EPR spectrometer operating at 1200 MHz with a large pole gap (50 cm).

Related Experiment Videos

  • Integration of clinical operation features, including a reference arm phasing indicator and a 2-level RF amplifier.
  • Design of specialized resonators and holders for various measurement sites (surface, deep tissue, teeth) to ensure patient comfort and minimize motion artifacts.

    • Main Results:

    • The spectrometer facilitates comfortable subject positioning for measurements anywhere on the human body.
    • Developed resonators and holders effectively prevent motion artifacts during measurements.
    • The system is validated for initial applications including surface and deep-site oximetry and dental radiation dosimetry.

    Conclusions:

    • A novel EPR spectrometer optimized for human use has been successfully designed and constructed.
    • The instrument's features support clinical operations and diverse in vivo applications.
    • This technology holds promise for advancing EPR spectroscopy in clinical diagnostics and biological research.